A Beginner’s Guide to the Endocannabinoid System and How CBD Can Affect Your Health

A Beginner’s Guide to the Endocannabinoid System and How CBD Can Affect Your Health

CBD has been touted as a pain remedya sleep aid, a reducer of anxiety—there’s even science showing it can have a positive impact on skin health. But how does CBD actually work? With all the buzz around CBD as a wellness ingredient, it’s worth asking how this non-intoxicating cannabinoid can actually impact your health. 

The answer is found in a recently discovered bodily system called the endocannabinoid system, or ECS for short. Bradley E. Alger, a doctor at the University of Maryland School of Medicine called the ECS “one of the most important physiologic systems involved in establishing and maintaining human health.” (If you’re really wanting the full scientific deep dive into the ECS, Dr. Alger’s 2013 article Getting High on the Endocannabinoid System, is an amazing read and, you don’t have to be a chemistry expert to understand it).

You Have an Endocannabinoid System and You Have to Take Care of It

In the 1990s, while scientists were attempting to understand how THC impacts the human body, they made the discovery of the ECS. It turns out that our bodies actually have cannabinoid receptors built into them and that they also produce their own cannabinoids (called endocannabinoids). There is a vast network within our own bodies that is ready to take cannabinoids like THC and CBD, which is one of the reasons humans react to them.

All mammals have a sophisticated network of receptors called the ECS that is distributed throughout their peripheral and central nervous systems (yep, animals have them too). Your brain, connective tissue, glands, organs, and immune cells all contain these receptors. (Consider your body's receptors as small locks with the cannabinoids you consume as the ideal keys.)

Although researchers still don't fully understand how the ECS works functions completely, it is undeniably an important system for maintaining human health. Homeostasis, or equilibrium, is established in the body via the ECS. The ECS is assisting you in cooling off while you perspire in the heat. The ECS is pushing you toward sleep if you're exhausted and have trouble keeping your eyes open. Experts contend that when the body deviates from its optimal range, whether in terms of body temperature, appetite, or immunological response, the ECS strives to bring the body back into the Goldilocks zone.

The ECS, Cannabinoid Receptors and CBD

Within the ECS, there are two types of cannabinoid receptors, known as CB 1 and CB 2. CB 1 receptors are located in your brain and spinal cord nerves, while CB 2 receptors are found in your peripheral nervous system, digestive system and immune system. Both types of receptors are found in the skin

THC, the famously intoxicating cannabinoid, works mostly on CB 1 receptors, which are of course found in the brain. CBD doesn’t attach to either type of these receptors, but does optimize their performance (i.e., CBD has been shown to be effective for interrupting the transmission of signals that tell us when we’re in pain). 

  • CBD increases blood flow to the brain, and is able to target a specific serotonin receptor, the serotonin 1A receptor, which may explain its anti-anxiety effects as well as its ability to control drug cravings in people recovering from opioid addiction 
  • CBD directly binds to other receptors which mediate pain perception and inflammation
  • A team of Stony Brook University scientists found that CBD raises endocannabinoid levels in the brain’s synapses (this action may explain how CBD confers neuroprotective effects against seizures, as well as many other brain health benefits)
  • CBD’s anti-inflammatory and anti-anxiety effects are thought to be linked to the way CBD boosts adenosine levels in the brain

Scientists are still working to understand all of the specifics of how CBD operates in the body—but evidence indicates that by stimulating the endocannabinoid system, CBD promotes homeostasis, calms the nervous system, reduces pain sensation and decreases inflammation.

The takeaway? The endocannabinoid system is involved in many of your body’s most important functions, and CBD promotes balance in your body by stimulating your endocannabinoid system. As Annie Nelson famously stated, “You have an endocannabinoid system and you have to take care of it.” In the same way you take care of your cardiovascular system by exercising, or your skeletal system by taking calcium, you can support your ECS with CBD.